THE POTENTIAL OF NANOTECHNOLOGY IN TARGETED DRUG DELIVERY SYSTEMS FOR VETERINARY ONCOLOGY TREATMENTS

Abstract

Nanotechnology has emerged as a powerful tool for improving cancer therapy through precise and targeted drug delivery, with growing relevance in veterinary oncology. This study evaluated the potential of nanotechnology-based targeted drug delivery systems using a mixed-method experimental approach that combined nanoparticle formulation and characterization with in-vitro and in-vivo therapeutic assessment in veterinary cancer models. The results demonstrated that the synthesized nanoparticles exhibited uniform nanoscale dimensions, favorable surface charge, and high drug encapsulation efficiency, ensuring formulation stability and prolonged systemic circulation. Controlled release studies confirmed sustained drug delivery over time, while cellular uptake analyses showed significantly enhanced internalization of targeted nanoparticles compared with non-targeted controls. In-vivo evaluations revealed marked tumor volume reduction, high tumor inhibition rates, and preferential biodistribution of nanocarriers to tumor-associated tissues, confirming effective passive and active targeting. Importantly, hematological and biochemical analyses indicated minimal systemic toxicity, which was further reflected in improved quality-of-life scores and extended survival durations in treated animals. Overall, the findings demonstrate that nanotechnology-based targeted drug delivery systems can enhance therapeutic efficacy while reducing adverse effects, offering a promising and clinically relevant approach for improving cancer management in veterinary medicine.